A syringe adapter includes a housing having a first end and a second end and defining an interior space, a seal arrangement received within the interior space of the housing, a connector body positioned adjacent the first end of the housing and configured to be connected with a syringe barrel with the connector body secured to the housing and rotatable relative to the housing in first and second directions, and a cannula secured to the connector body. The connector body is axially fixed relative to the housing. The seal arrangement is configured to cooperate with the cannula to provide a sealed transfer of fluids through the cannula to a mating connector.