Invention Application
- Patent Title: FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS
- Patent Title (中): 熔融杂环化合物作为离子通道调节剂
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Application No.: US15188701Application Date: 2016-06-21
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Publication No.: US20160362421A1Publication Date: 2016-12-15
- Inventor: Britton Kenneth Corkey , Elfatih Elzein , Michael Graupe , Juan Guerrero , Robert H. Jiang , Rao V. Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Gregory Notte , Eric Q. Parkhill , Thao Perry , Chandrasekar Venkataramani , Jeff Zablocki
- Applicant: Gilead Sciences, Inc.
- Main IPC: C07D498/10
- IPC: C07D498/10 ; C07D401/04 ; C07D403/04 ; C07D413/06 ; C07D403/06 ; C07D413/14 ; C07D417/06 ; C07D403/12 ; C07D401/12 ; C07D401/14 ; C07D237/32 ; C07D417/12 ; C07D401/06 ; C07D265/22 ; C07D279/08 ; C07D217/26 ; C07D405/12 ; C07D253/08

Abstract:
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
Public/Granted literature
- US09682998B2 Fused heterocyclic compounds as ion channel modulators Public/Granted day:2017-06-20
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