Invention Application
US20170001968A1 AMINOTRIAZOLE- AND AMINOTETRAZOLE-BASED KDM1A INHIBITORS AS EPIGENETIC MODULATORS
审中-公开
氨基腈和氨基三唑基KDM1A抑制剂作为调节剂
- Patent Title: AMINOTRIAZOLE- AND AMINOTETRAZOLE-BASED KDM1A INHIBITORS AS EPIGENETIC MODULATORS
- Patent Title (中): 氨基腈和氨基三唑基KDM1A抑制剂作为调节剂
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Application No.: US15115342Application Date: 2015-02-06
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Publication No.: US20170001968A1Publication Date: 2017-01-05
- Inventor: Patrick M. WOSTER , Craig J. KUTZ
- Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
- Applicant Address: US SC Charleston
- Assignee: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
- Current Assignee: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
- Current Assignee Address: US SC Charleston
- International Application: PCT/US15/14830 WO 20150206
- Main IPC: C07D249/14
- IPC: C07D249/14 ; C07D405/12 ; C07D403/12 ; C07D257/06
Abstract:
In some aspects, the present invention provides compounds of the formula (IV), wherein the variables are as defined herein, which may be used as inhibitors of histone demethylase or spermine oxidase. Also provided herein are pharmaceutical compositions of the compounds and methods using the compounds in the treatment of diseases such as cancer and cardiovascular disease.
Public/Granted literature
- US10118903B2 Aminotriazole-based KDM1A inhibitors as epigenetic modulators Public/Granted day:2018-11-06
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