公开(公告)号：US20170001968A1

公开(公告)日：2017-01-05

申请号：US15115342

申请日：2015-02-06

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Patrick M. WOSTER ,  Craig J. KUTZ

IPC: C07D249/14 ,  C07D405/12 ,  C07D403/12 ,  C07D257/06

CPC classification number: C07D249/14 ,  C07D257/06 ,  C07D403/12 ,  C07D405/12

Abstract: In some aspects, the present invention provides compounds of the formula (IV), wherein the variables are as defined herein, which may be used as inhibitors of histone demethylase or spermine oxidase. Also provided herein are pharmaceutical compositions of the compounds and methods using the compounds in the treatment of diseases such as cancer and cardiovascular disease.

Abstract translation: 在一些方面，本发明提供式（IV）化合物，其中变量如本文所定义，其可用作组蛋白脱甲基酶或精胺氧化酶的抑制剂。 本文还提供了化合物的药物组合物和使用该化合物治疗诸如癌症和心血管疾病的疾病的方法。