Invention Application
US20170002000A1 NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-b]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-c]PYRIDAZINES AS LRRK2 INHIBITORS
审中-公开
新的3,4-取代的1H-吡咯并[2,3-b]吡啶和4,5-取代的-7H-吡咯并[2,3-c]吡咯烷作为LRRK2抑制剂
![NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-b]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-c]PYRIDAZINES AS LRRK2 INHIBITORS](/docs/US/2017-01-05/US20170002000A1/abs.jpg.600x600.jpg)
- Patent Title: NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-b]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-c]PYRIDAZINES AS LRRK2 INHIBITORS
- Patent Title (中): 新的3,4-取代的1H-吡咯并[2,3-b]吡啶和4,5-取代的-7H-吡咯并[2,3-c]吡咯烷作为LRRK2抑制剂
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Application No.: US15104659Application Date: 2014-12-03
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Publication No.: US20170002000A1Publication Date: 2017-01-05
- Inventor: Paul Galatsis , Matthew Merrill Hayward , Bethany Lyn Kormos , Travis T. Wager , Lei Zhang , Jaclyn Louise Henderson , Ravi G. Kurumbail , Patrick Robert Verhoest , Antonia Friederike Stepan
- Applicant: PFIZER INC.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- International Application: PCT/IB2014/066563 WO 20141203
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D491/08 ; C07D498/08 ; C07D519/00 ; C07D487/04
![NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-b]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-c]PYRIDAZINES AS LRRK2 INHIBITORS](/abs-image/US/2017/01/05/US20170002000A1/abs.jpg.150x150.jpg)
Abstract:
The present invention provides novel 3,4-disubstituted-1H-pyrrolo[2,3-b]pyridine derivatives and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazine derivatives of Formula I, and the pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4 and X are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.
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