Invention Application
- Patent Title: BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE
- Patent Title (中): 苯并噻唑氧杂环丁酮化合物及其使用方法
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Application No.: US15200307Application Date: 2016-07-01
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Publication No.: US20170002022A1Publication Date: 2017-01-05
- Inventor: Marie-Gabrielle Braun , Emily Hanan , Steven T. Staben , Robert Andrew Heald , Calum MacLeod , Richard Elliott
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Main IPC: C07D498/04
- IPC: C07D498/04 ; A61K31/553 ; A61K45/06

Abstract:
Described herein are benzoxazepin oxazolidinone compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such PI3K modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon PI3K dysregulation.
Public/Granted literature
- US09643980B2 Benzoxazepin oxazolidinone compounds and methods of use Public/Granted day:2017-05-09
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