Invention Application
US20170014375A1 PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE DOSE OF POMIFERIN FOR TREATING CANCERS
审中-公开
包含POMIFININ治疗癌症有效剂量的药物组合物
- Patent Title: PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE DOSE OF POMIFERIN FOR TREATING CANCERS
- Patent Title (中): 包含POMIFININ治疗癌症有效剂量的药物组合物
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Application No.: US14799541Application Date: 2015-07-14
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Publication No.: US20170014375A1Publication Date: 2017-01-19
- Inventor: Kam Wai WONG , Yuen Kwan LAW , Liang LIU , Su-Wei XU
- Applicant: Macau University of Science and Technology
- Main IPC: A61K31/352
- IPC: A61K31/352

Abstract:
The present invention provides a compound of formula (I) as a SERCA inhibitor for treating cancers, a pharmaceutical composition comprising said compound, and methods of using said compound for treating cancers and/or inducing cell death in cells of said cancers. Said cancers include but not limited to cervical, lung, liver, breast, and prostate cancer. Said cancers also include drug-resistant and/or apoptosis-resistant cancers such as isogenic drug-resistant colon cancer. The subject being administered with said compound or the composition comprising thereof can be human or animal subject. Said methods for treating cancers and/or inducing cell death can be a targeting treatment for certain cancers.
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