公开(公告)号：US20170014375A1

公开(公告)日：2017-01-19

申请号：US14799541

申请日：2015-07-14

Applicant: Macau University of Science and Technology

Inventor： Kam Wai WONG ,  Yuen Kwan LAW ,  Liang LIU ,  Su-Wei XU

IPC: A61K31/352

CPC classification number: A61K31/352

Abstract: The present invention provides a compound of formula (I) as a SERCA inhibitor for treating cancers, a pharmaceutical composition comprising said compound, and methods of using said compound for treating cancers and/or inducing cell death in cells of said cancers. Said cancers include but not limited to cervical, lung, liver, breast, and prostate cancer. Said cancers also include drug-resistant and/or apoptosis-resistant cancers such as isogenic drug-resistant colon cancer. The subject being administered with said compound or the composition comprising thereof can be human or animal subject. Said methods for treating cancers and/or inducing cell death can be a targeting treatment for certain cancers.

Abstract translation: 本发明提供了作为用于治疗癌症的SERCA抑制剂的式（I）化合物，包含所述化合物的药物组合物，以及使用所述化合物治疗癌症和/或诱导所述癌症细胞中的细胞死亡的方法。 所述癌症包括但不限于宫颈癌，肺癌，肝癌，乳腺癌和前列腺癌。 所述癌症还包括耐药性和/或细胞凋亡抵抗性癌症，例如同基因耐药结肠癌。 给予所述化合物或包含其的组合物的受试者可以是人或动物受试者。 用于治疗癌症和/或诱导细胞死亡的所述方法可以是某些癌症的靶向治疗。