Invention Application
US20170029390A1 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AND 1,1,1-TRIFLUORO-4-HYDROXYBUTAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS
审中-公开
1,1,1-三氟-3-羟基丙-2-烯酸酯衍生物和1,1,1-三氟-4-羟基丁-2-烯酸酯衍生物作为磁性抑制剂
- Patent Title: 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AND 1,1,1-TRIFLUORO-4-HYDROXYBUTAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS
- Patent Title (中): 1,1,1-三氟-3-羟基丙-2-烯酸酯衍生物和1,1,1-三氟-4-羟基丁-2-烯酸酯衍生物作为磁性抑制剂
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Application No.: US15221658Application Date: 2016-07-28
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Publication No.: US20170029390A1Publication Date: 2017-02-02
- Inventor: CHRISTOPHER RYAN BUTLER , LAURA ANN MCALLISTER , ELIZABETH MARY BECK , MICHAEL AARON BRODNEY , ADAM MATTHEW GILBERT , CHRISTOPHER JOHN HELAL , DOUGLAS SCOTT JOHNSON , JUSTIN IAN MONTGOMERY , STEVEN VICTOR O'NEIL , BRUCE NELSEN ROGERS , PATRICK ROBERT VERHOEST , DAMIEN WEBB
- Applicant: PFIZER INC.
- Applicant Address: US NY NEW YORK
- Assignee: PFIZER INC.
- Current Assignee: PFIZER INC.
- Current Assignee Address: US NY NEW YORK
- Main IPC: C07D295/14
- IPC: C07D295/14 ; C07D401/04 ; C07D403/04 ; C07D498/10 ; C07D491/107 ; C07D405/14 ; C07D471/10 ; C07D487/04 ; C07D211/48 ; C07D471/08 ; C07D515/10 ; C07F9/6561 ; C07D401/14 ; C07D401/12
Abstract:
The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.
Public/Granted literature
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