Invention Application
- Patent Title: HUMANIZED ANTIBODIES AGAINST CEACAM1
- Patent Title (中): 人类抗体对CEACAM1
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Application No.: US15306664Application Date: 2015-04-27
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Publication No.: US20170044270A1Publication Date: 2017-02-16
- Inventor: Tehila BEN-MOSHE , Yair SAPIR , Ilana MANDEL , Gal MARKEL , Jacob SCHACHTER , Rona ORTENBERG , Francis Joseph CARR , Robert George E. HOLGATE , Timothy David JONES
- Applicant: CCAM BIOTHERAPEUTICS LTD.
- Applicant Address: IL Hod HaSharon
- Assignee: CCAM BIOTHERAPEUTICS LTD.
- Current Assignee: CCAM BIOTHERAPEUTICS LTD.
- Current Assignee Address: IL Hod HaSharon
- International Application: PCT/IL2015/050433 WO 20150427
- Main IPC: C07K16/30
- IPC: C07K16/30 ; G01N33/574 ; C07K16/28 ; A61K35/17 ; A61K39/395 ; A61K45/06

Abstract:
Humanized antibodies, capable of specific binding to human CEACAM1 molecules containing human-to-murine back-mutations in non-CDR variable regions, and their encoding polynucleotide sequences are provided. Pharmaceutical compositions comprising these antibodies as well as methods of their use in treating and diagnosing cancer and other conditions are also provided.
Public/Granted literature
- US10550196B2 Humanized antibodies against CEACAM1 Public/Granted day:2020-02-04
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