公开(公告)号：US20170044270A1

公开(公告)日：2017-02-16

申请号：US15306664

申请日：2015-04-27

Applicant: CCAM BIOTHERAPEUTICS LTD.

Inventor： Tehila BEN-MOSHE ,  Yair SAPIR ,  Ilana MANDEL ,  Gal MARKEL ,  Jacob SCHACHTER ,  Rona ORTENBERG ,  Francis Joseph CARR ,  Robert George E. HOLGATE ,  Timothy David JONES

IPC: C07K16/30 ,  G01N33/574 ,  C07K16/28 ,  A61K35/17 ,  A61K39/395 ,  A61K45/06

Abstract: Humanized antibodies, capable of specific binding to human CEACAM1 molecules containing human-to-murine back-mutations in non-CDR variable regions, and their encoding polynucleotide sequences are provided. Pharmaceutical compositions comprising these antibodies as well as methods of their use in treating and diagnosing cancer and other conditions are also provided.

Abstract translation: 提供能够特异性结合含有非CDR区域中的人到鼠反向突变的人CEACAM1分子的人源化抗体及其编码多核苷酸序列。 还提供了包含这些抗体的药物组合物及其用于治疗和诊断癌症和其它病症的方法。