Invention Application
US20170049779A1 FLAGELLAR AND NEEDLE COMPLEX (INJECTOSOME) LOOP AS ANTI BACTERIAL DRUG TARGET
审中-公开
鳄梨和针头复合物（注射成型）作为抗真菌药物目标
- Patent Title: FLAGELLAR AND NEEDLE COMPLEX (INJECTOSOME) LOOP AS ANTI BACTERIAL DRUG TARGET
- Patent Title (中): 鳄梨和针头复合物（注射成型）作为抗真菌药物目标
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Application No.: US15237244Application Date: 2016-08-15
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Publication No.: US20170049779A1Publication Date: 2017-02-23
- Inventor: Fadel Alexis SAMATEY , Vladimir A. MESHCHERYAKOV , Hideyuki MATSUNAMI , Akio KITAO
- Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION
- Applicant Address: JP Kunigami-gun
- Assignee: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION
- Current Assignee: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION
- Current Assignee Address: JP Kunigami-gun
- Main IPC: A61K31/522
- IPC: A61K31/522 ; A61K31/505
Abstract:
The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.
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