公开(公告)号：US20160002239A1

公开(公告)日：2016-01-07

申请号：US14770708

申请日：2014-02-27

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Fadel Alexis SAMATEY ,  Vladimir A MESHCHERYAKOV ,  Hideyuki MATSUNAMI ,  Akio KITAO

IPC: C07D473/08 ,  C07D239/49 ,  C12Q1/02

CPC classification number: C07D473/08 ,  A61K31/505 ,  A61K31/522 ,  C07D239/49 ,  C12Q1/025 ,  C12Q1/18 ,  G01N2333/255 ,  G01N2500/04 ,  Y02A50/406 ,  Y02A50/473 ,  Y02A50/475

Abstract: The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof. Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.

Abstract translation: 本发明涉及一种使用针型III分泌系统筛选通过强毒细菌分泌毒素至宿主细胞质的化合物的方法。 通过筛选与来自鼠伤寒沙门氏菌或其旁系同源物的膜蛋白FlhB的细胞质结构域的环区相互作用的化合物来选择本发明的化合物。 还提供了包括本发明化合物的组合物，该化合物的用途和治疗由毒性细菌引起的疾病的方法。

公开(公告)号：US20170049779A1

公开(公告)日：2017-02-23

申请号：US15237244

申请日：2016-08-15

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Fadel Alexis SAMATEY ,  Vladimir A. MESHCHERYAKOV ,  Hideyuki MATSUNAMI ,  Akio KITAO

IPC: A61K31/522 ,  A61K31/505

CPC classification number: A61K31/522 ,  A61K31/505 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  A61K2300/00

Abstract: The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.

Abstract translation: 本发明涉及一种使用针型III分泌系统筛选通过强毒细菌分泌毒素至宿主细胞质的化合物的方法。 通过筛选与鼠伤寒沙门氏菌或其旁系同源膜的膜蛋白FlhB的细胞质结构域的环区相互作用的化合物来选择本发明的化合物。组合物包括本发明化合物，该化合物的用途和方法 还提供了治疗由毒性细菌引起的疾病。