发明申请
- 专利标题： MODIFIED PSEUDOMONAS EXOTOXIN A
- 专利标题（中）： 改良PSEUDOMONAS EXOTOXIN A
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申请号： US15191392申请日： 2016-06-23
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公开(公告)号： US20170051072A1公开(公告)日： 2017-02-23
- 发明人: Ira H. Pastan , Ronit Mazor , Masanori Onda , Byungkook Lee , Gerhard Niederfellner , Sabine Imhof-Jung , Ulrich Brinkmann , Werner Scheuer , Guy Georges
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv , Hoffmann-La Roche Inc.
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; A61K47/48 ; C07K14/21
摘要：
The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
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