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公开(公告)号：US20150099707A1
公开(公告)日：2015-04-09
申请号：US14505590
申请日：2014-10-03
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv , Hoffmann-La Roche Inc.
发明人： Ira H. Pastan , Ronit Mazor , Masanori Onda , Byungkook Lee , Gerhard Niederfellner , Sabine Imhof-Jung , Ulrich Brinkmann , Werner Scheuer , Guy Georges
CPC分类号： C07K16/30 , A61K31/337 , A61K38/00 , A61K39/39558 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6871 , A61K2039/505 , C07K14/21 , C07K16/1214 , C07K16/303 , C07K16/40 , C07K2317/24 , C07K2317/55 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/30 , C07K2319/33 , C07K2319/50 , C07K2319/55 , A61K2300/00
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
摘要翻译： 本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。 本发明还提供相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 治疗或预防哺乳动物癌症的方法，抑制靶细胞生长的方法，生产PE的方法和制备嵌合分子的方法进一步由本发明提供。
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公开(公告)号：US20170051072A1
公开(公告)日：2017-02-23
申请号：US15191392
申请日：2016-06-23
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv , Hoffmann-La Roche Inc.
发明人： Ira H. Pastan , Ronit Mazor , Masanori Onda , Byungkook Lee , Gerhard Niederfellner , Sabine Imhof-Jung , Ulrich Brinkmann , Werner Scheuer , Guy Georges
CPC分类号： C07K16/30 , A61K31/337 , A61K38/00 , A61K39/39558 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6871 , A61K2039/505 , C07K14/21 , C07K16/1214 , C07K16/303 , C07K16/40 , C07K2317/24 , C07K2317/55 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/30 , C07K2319/33 , C07K2319/50 , C07K2319/55 , A61K2300/00
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
摘要翻译： 本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。 本发明还提供相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 治疗或预防哺乳动物癌症的方法，抑制靶细胞生长的方法，生产PE的方法和制备嵌合分子的方法进一步由本发明提供。
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3.发明申请PSEUDOMONAS EXOTOXIN A WITH LESS IMMUNOGENIC B CELL EPITOPES 审中-公开PSEUDOMONAS EXOTOXIN A与无免疫B细胞外周血单核细胞公开(公告)号：US20160046677A1
公开(公告)日：2016-02-18
申请号：US14927645
申请日：2015-10-30
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv
发明人： Ira H. Pastan , Masanori Onda , Wenhai Liu
CPC分类号： A61K38/164 , A61K38/00 , A61K47/48484 , C07K14/21 , C07K16/1214 , C07K16/2851 , C07K16/2896 , C07K16/30 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2319/01 , C07K2319/55
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more of amino acid residues E420, D463, Y481, L516, R563, D581, D589, and K606, wherein the amino acid residues are defined by reference to SEQ ID NO: 1. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
摘要翻译： 本发明提供了一种假单胞菌外毒素A（PE），其包含具有氨基酸残基E420，D463，Y481，L516，R563，D581，D589和K606中的一个或多个取代的氨基酸序列，其中定义了氨基酸残基 本发明还提供了相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 治疗或预防哺乳动物癌症的方法，抑制靶细胞生长的方法，生产PE的方法和制备嵌合分子的方法进一步由本发明提供。
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公开(公告)号：US20170216398A1
公开(公告)日：2017-08-03
申请号：US15488898
申请日：2017-04-17
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv
发明人： Ira H. Pastan , Masanori Onda , Wenhai Liu
CPC分类号： A61K38/164 , A61K38/00 , A61K47/48484 , C07K14/21 , C07K16/1214 , C07K16/2851 , C07K16/2896 , C07K16/30 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2319/01 , C07K2319/55
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more of amino acid residues E420, D463, Y481, L516, R563, D581, D589, and K606, wherein the amino acid residues are defined by reference to SEQ ID NO: 1. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and phaxinaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
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5.发明申请PSEUDOMONAS EXOTOXIN A WITH LESS IMMUNOGENIC T CELL AND/OR B CELL EPITOPES 有权具有较少免疫原性细胞和/或B细胞外膜的PSEUDOMONAS EXOTOXIN A公开(公告)号：US20160215025A1
公开(公告)日：2016-07-28
申请号：US15095470
申请日：2016-04-11
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv
发明人： Ira H. Pastan , Ronit Mazor , Masanori Onda , Aaron Vassall , Richard Beers , Jaime Eberle , Wenhai Liu
CPC分类号： C07K14/21 , A61K38/00 , C07K16/2896 , C07K2319/33 , C07K2319/55
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
摘要翻译： 本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。 本发明还提供相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 治疗或预防哺乳动物癌症的方法，抑制靶细胞生长的方法，生产PE的方法和制备嵌合分子的方法进一步由本发明提供。
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公开(公告)号：US20200181280A1
公开(公告)日：2020-06-11
申请号：US16429829
申请日：2019-06-03
申请人： The United States of America, as represented by the Secretary,Department of Health and Human Service , Hoffmann-La Roche Inc.
发明人： Ira H. Pastan , Ronit Mazor , Masanori Onda , Byungkook Lee , Gerhard Niederfellner , Sabine Imhof-Jung , Ulrich Brinkmann , Werner Scheuer , Guy Georges
IPC分类号： C07K16/30 , C07K14/21 , C07K16/12 , C07K16/40 , A61K31/337 , A61K47/68 , A61K39/395
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
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公开(公告)号：US09388222B2
公开(公告)日：2016-07-12
申请号：US14505590
申请日：2014-10-03
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Hoffmann-La Roche Inc.
发明人： Ira H. Pastan , Ronit Mazor , Masanori Onda , Byungkook Lee , Gerhard Niederfellner , Sabine Imhof-Jung , Ulrich Brinkmann , Guy Georges
CPC分类号： C07K16/30 , A61K31/337 , A61K38/00 , A61K39/39558 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6871 , A61K2039/505 , C07K14/21 , C07K16/1214 , C07K16/303 , C07K16/40 , C07K2317/24 , C07K2317/55 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/30 , C07K2319/33 , C07K2319/50 , C07K2319/55 , A61K2300/00
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
摘要翻译： 本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。 本发明还提供相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 治疗或预防哺乳动物癌症的方法，抑制靶细胞生长的方法，生产PE的方法和制备嵌合分子的方法进一步由本发明提供。
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公开(公告)号：US20210024648A1
公开(公告)日：2021-01-28
申请号：US16785911
申请日：2020-02-10
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Hoffmann-La Roche Inc.
发明人： Ira H. Pastan , Ronit Mazor , Masanori Onda , Byungkook Lee , Gerhard Niederfellne , Sabine Imhof-Jung , Ulrich Brinkmann , Guy Georges
IPC分类号： C07K16/30 , C07K16/12 , A61K47/68 , A61K39/395 , A61K31/337 , C07K16/40 , C07K14/21
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
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