Invention Application
US20170057932A1 BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS
审中-公开
联苯胺和苯基吡啶类作为P2X3和P2X2 / 3拮抗剂
- Patent Title: BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS
- Patent Title (中): 联苯胺和苯基吡啶类作为P2X3和P2X2 / 3拮抗剂
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Application No.: US15347614Application Date: 2016-11-09
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Publication No.: US20170057932A1Publication Date: 2017-03-02
- Inventor: Chris Allen Broka , Ronald Charles Hawley
- Applicant: Roche Palo Alto LLC
- Applicant Address: US CA South San Francisco
- Assignee: Roche Palo Alto LLC
- Current Assignee: Roche Palo Alto LLC
- Current Assignee Address: US CA South San Francisco
- Main IPC: C07D241/12
- IPC: C07D241/12
Abstract:
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted phenyl or optionally substituted pyridinyl, and R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
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