Invention Application
- Patent Title: HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH
- Patent Title (中): 基于可变域VL和衍生VHH的高亲和力和稳定抗体
-
Application No.: US15254225Application Date: 2016-09-01
-
Publication No.: US20170066843A1Publication Date: 2017-03-09
- Inventor: Andrey Borisovich ULITIN , Stanislav Rudolfovich EVDOKIMOV , Valeriy Vladimirovich SOLOVIEV , Yulia Sergeevna CHERNYH , Olga Vladimirovna GONCHAROVA , Dmitriy Valerievich KORZHAVIN , Tatyana Veniaminovna CHERNOVSKAYA , Timofey Aleksandrovich NEMANKIN , Roman Alexeevich IVANOV , Dmitriy Valentinovich MOROZOV , Victoria Mikhailovna EKIMOVA , Ekaterina Vladimirovna SOFRONOVA , Yakov Yurevich USTYUGOV
- Applicant: CLOSED JOINT STOCK COMPANY "BIOCAD"
- Priority: RU2014138740 20140926
- Main IPC: C07K16/46
- IPC: C07K16/46 ; A61K45/06 ; C07K16/24 ; A61K39/395
Abstract:
The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.
Public/Granted literature
- US10442869B2 Anti-IL-17A Antibodies Public/Granted day:2019-10-15
Information query
