An injection catheter includes a drive mechanism, an elongate, flexible tubular body, and a first inner member. The tubular body has a distal end portion, a proximal end portion, and defines a first lumen extending therebetween. The first inner member includes a proximal end coupled to the drive mechanism and is rotatably disposed within the first lumen. The first inner member and the first lumen define an annular gap therebetween configured to deliver a therapeutic agent contained therein from the proximal end portion to the distal end portion of the tubular body when the first inner member is rotated within the lumen such that shear stresses exerted on the therapeutic agent are less than 500 pascals.