- 专利标题: COMPARTMENTALISED SCREENING BY MICROFLUIDIC CONTROL
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申请号: US15331445申请日: 2016-10-21
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公开(公告)号: US20170102381A1公开(公告)日: 2017-04-13
- 发明人: Andrew David Griffiths , David A. Weitz , Darren Roy Link , Keunho Ahn , Jerome Bibette
- 申请人: President and Fellows of Harvard College , Medical Research Council
- 主分类号: G01N33/543
- IPC分类号: G01N33/543 ; B01F3/08 ; G01N21/64 ; C12Q1/42 ; B01J19/00 ; G01N15/14 ; B01F13/00 ; G01N33/573
摘要:
The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
公开/授权文献
- US10371699B2 Compartmentalised screening by microfluidic control 公开/授权日:2019-08-06