According to an aspect of the inventive concept, there is provided a system for detecting vulnerabilities of communication protocol software, including: a field selection module selecting message fields of a communication protocol of an industrial control system; a value set configuration module configuring first value sets with respect to the respective message fields selected by the field selection module; a test case generation module generating first test cases by Cartesian product of the first value sets; a test module generating first code coverage data by testing the communication protocol software of the industrial control system based on the first test cases; and a code coverage analysis module analyzing the first code coverage data, wherein the field selection module selects concentration message fields which influence the first code coverage data among the message fields according to an analysis result of the code coverage analysis module.