Invention Application
- Patent Title: NOVEL CRYSTALLINE FORM OF 5-CHLORO-N-(METHYL)THIOPHENE-2-CARBOXAMIDE METHANESULFONATE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
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Application No.: US15325521Application Date: 2014-07-18
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Publication No.: US20170152251A1Publication Date: 2017-06-01
- Inventor: Soongyu CHOI , Jungsub CHOI , So-Hyun YOON , Yoo Hoon KIM , Jae Yeon KIM , Suk Ho LEE , Young Lag CHO , Ho Young SONG , Dae Yon LEE , Sung Yoon BAEK , Sang Eun CHAE , Tae Kyo PARK , Sung Ho WOO , Yong Zu KIM
- Applicant: GREEN CROSS CORPORATION , LEGOCHEM BIOSCIENCES,INC.
- Applicant Address: KR Yongin-si, Gyeonggi-do KR Daejeon
- Assignee: GREEN CROSS CORPORATION,LEGOCHEM BIOSCIENCES,INC.
- Current Assignee: GREEN CROSS CORPORATION,LEGOCHEM BIOSCIENCES,INC.
- Current Assignee Address: KR Yongin-si, Gyeonggi-do KR Daejeon
- International Application: PCT/KR2014/006555 WO 20140718
- Main IPC: C07D413/14
- IPC: C07D413/14

Abstract:
The present invention relates to a novel crystalline form of 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate and a pharmaceutical composition containing the same. The novel crystalline form of a compound according to the present invention exhibits excellent stability even in high-temperature and humidity environments, and thus can be favorably used to prevent or treat diseases, such as thrombosis, myocardial infarction, atherosclerosis, inflammation, stroke, angina pectoris, restenosis after angioplasty, and thromboembolism.
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