Systems and methods are disclosed to detect and/or classify electrophysiological signals as motor events. In some embodiments, a method may include: recording a first plurality of electrophysiological signals from a first plurality of probes inserted into the left hemisphere of the brain; recording a second plurality of electrophysiological signals from a second plurality of probes inserted into the right hemisphere of the brain; pre-processing the first plurality of electrophysiological signals and the second plurality of electrophysiological signals; bipolar re-referencing the first plurality of electrophysiological signals and the second plurality of electrophysiological signals; determining an optimal pair of electrophysiological signals from the bipolar re-referenced first plurality of electrophysiological signals and the bipolar re-referenced second plurality of electrophysiological signals; matching the optimal pair of electrophysiological signals with a template; and detecting motor events from the matching.