公开(公告)号：US10540782B2

公开(公告)日：2020-01-21

申请号：US15814232

申请日：2017-11-15

Applicant: Colorado Seminary Which Owns and Operates the University of Denver

Inventor： Alessandro Benini ,  Matthew J. Rutherford ,  Kimon P. Valavanis

IPC: G06K9/00 ,  G06T7/73 ,  G06T7/60 ,  G06T1/20 ,  G06T7/13

Abstract: A method for estimating a pose of a first object in relation to a second object, the second object comprising a visual marker comprising a plurality of ellipses comprises capturing a video image of the visual marker with an image capture device on the first object, then pre-processing frames of the video image on a graphics processing unit. The method comprises detecting the visual marker by finding contours in the frames to identify the plurality of ellipses and determining that a pattern of the plurality of ellipses match a known pattern of the visual marker. Then the method comprises obtaining coordinates of two or more of the plurality of ellipses of the visual marker, estimating the pose of the first object in relation to the second object by inputting the coordinates of the plurality of ellipses into a pose estimation algorithm, and filtering results of the pose estimation algorithm.

公开(公告)号：US10538339B2

公开(公告)日：2020-01-21

申请号：US15318882

申请日：2015-06-19

Applicant: COLORADO SEMINARY, which owns and operates the University of Denver

Inventor： Stephen A. Conyers ,  Nikolaos Vitzilaios ,  Matthew J. Rutherford ,  Kimon P. Valavanis

IPC: B64F1/00 ,  B64F1/10 ,  B60K1/02 ,  B62D7/14 ,  B64C39/02 ,  H02J7/35 ,  H02S99/00

Abstract: A mobile self-leveling landing platform vehicle is disclosed that includes a landing surface and one or more wheel assemblies. Each wheel assembly includes a wheel, a control arm coupled with the wheel and the body of the landing platform vehicle, and an actuator coupled with the control arm and the body of the platform vehicle. Methods for self-leveling the landing platform vehicle are also disclosed.

公开(公告)号：US20170137150A1

公开(公告)日：2017-05-18

申请号：US15318882

申请日：2015-06-19

Applicant: COLORADO SEMINARY, which owns and operates the University of Denver

Inventor： Stephen A. CONYERS ,  Nikkos VITZILAIOS ,  Matthew J. RUTHERFORD ,  Kimon P. VALAVANIS

IPC: B64F1/00 ,  B64C39/02 ,  H02J7/35 ,  B60K1/02 ,  H02S99/00 ,  B64F1/10 ,  B62D7/14

Abstract: A mobile self-leveling landing platform vehicle is disclosed that includes a landing surface and one or more wheel assemblies. Each wheel assembly includes a wheel, a control arm coupled with the wheel and the body of the landing platform vehicle, and an actuator coupled with the control arm and the body of the platform vehicle. Methods for self-leveling the landing platform vehicle are also disclosed.

公开(公告)号：US20160025845A1

公开(公告)日：2016-01-28

申请号：US14773525

申请日：2014-03-10

Applicant: Moses A. ALLISTAIR ,  Kimon P. VALAVANIS ,  Matthew J. RUTHERFORD ,  COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER

Inventor： MOSES A. ALLISTAIR ,  KIMON P. VALAVANIS

IPC: G01S13/34 ,  G01S7/35 ,  G01S13/04 ,  G01S13/93

CPC classification number: G01S13/34 ,  G01S7/03 ,  G01S7/354 ,  G01S7/415 ,  G01S13/04 ,  G01S13/348 ,  G01S13/584 ,  G01S13/9303

Abstract: A RADAR apparatus may be used in target detection and/or avoidance. The RADAR apparatus may include a microwave front end configured to transmit and receive RF signals, an analog signal conditioning module coupled with the microwave front end module that conditions RF signals received at the microwave front end module, and a digital signal processing module coupled with the analog signal conditioning module that detects presence and range of one or more targets based on the filtered RF signals.

Abstract translation: RADAR装置可用于目标检测和/或回避。 RADAR装置可以包括被配置为发送和接收RF信号的微波前端，与微波前端模块耦合的模拟信号调节模块，其调节在微波前端模块处接收的RF信号，以及与该微波前端模块耦合的数字信号处理模块 模拟信号调节模块，其基于滤波的RF信号检测一个或多个目标的存在和范围。

公开(公告)号：US20140336221A1

公开(公告)日：2014-11-13

申请号：US14273411

申请日：2014-05-08

Applicant: Colorado Seminary, Which Owns and Operates The University Of Denver ,  Regis University

Inventor： Scott Dusan Pegan ,  Kateri Ahrendt ,  Glenn C. Capodagli ,  Bryan Cowen

IPC: C07D215/48 ,  A01N43/90 ,  C12Q1/18 ,  C07D413/04 ,  C07D417/04 ,  A01N43/42 ,  C07D401/04

CPC classification number: C07D215/48 ,  A01N43/42 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04 ,  C12Q1/527 ,  G01N2333/988 ,  G01N2500/04

Abstract: This invention provides a family of compounds that inhibit Class II fructose 1,6-bisphosphate aldolase (FBA), which is implicated in the pathogenic activity of a broad range of bacterial and parasitic agents. The compounds were identified by empirical testing, and provide a basis for further derivatization and optimization of 8-hydroxyquinoline-2-carboxylic acid and related compounds. Crystal structure shows that the compounds don't bind directly to the catalytic site of the enzyme, and so are not defined simply as substrate analogs. Instead, they create a pocket by induced fit, resulting a powerful and specific inhibitory effect on FBA activity.

Abstract translation: 本发明提供一种抑制II型果糖1,6-二磷酸醛缩酶（FBA）的化合物家族，其涉及广泛的细菌和寄生虫的致病活性。 通过实验检验鉴定出化合物，为进一步的8-羟基喹啉-2-羧酸衍生化和优化提供依据。 晶体结构显示这些化合物不直接与酶的催化位点结合，因此不被简单地定义为底物类似物。 相反，他们通过诱导拟合创建口袋，从而对FBA活动产生强大而具体的抑制作用。

公开(公告)号：USD818046S1

公开(公告)日：2018-05-15

申请号：US29585482

申请日：2016-11-23

Applicant: Colorado Seminary Which Owns and Operates the University of Denver

Designer： Alessandro Benini ,  Matthew J. Rutherford ,  Kimon P. Valavanis

公开(公告)号：US09795665B2

公开(公告)日：2017-10-24

申请号：US14421120

申请日：2013-08-13

Applicant: The United States of America as Represented by the Secretary of the Department of Health and Human Services ,  COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER

Inventor： Eric Bergeron ,  Scott Dusan Pegan ,  Stuart T. Nichol ,  Michelle Kay Deaton

IPC: C12N7/00 ,  A61K39/12 ,  C12Q1/04 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2760/12034 ,  C12Q1/04 ,  G01N2333/175 ,  Y02A50/397

Abstract: The genetically modified nairoviruses of this invention possesses a viral ovarian tumor protease with decreased ability to remove ubiquitin (Ub) and ISG15 tags that the human organism uses to label proteins for removal. Exemplary are Crimean-Congo hemorrhagic fever virus and Erve virus. Unlike complete knockout strains, the modified virus retains enough activity for replication in a human cell line. This creates an immunogenic and non-pathogenic virus that can be used as an effective live vaccine agent for prophylaxis and treatment.

公开(公告)号：US20170156622A1

公开(公告)日：2017-06-08

申请号：US15369707

申请日：2016-12-05

Applicant: Colorado Seminary, which owns and operates the University of Denver

Inventor： Mohammad H. Mahoor ,  Soroush Niketeghad ,  Adam O. Hebb ,  Sara J. Hanrahan ,  Joshua Nedrud ,  Hosein M. Golshan

IPC: A61B5/0484 ,  A61B5/04 ,  A61N1/36 ,  A61B5/11 ,  A61N1/05 ,  A61B5/00 ,  A61B5/0478

CPC classification number: A61B5/0484 ,  A61B5/04012 ,  A61B5/0478 ,  A61B5/11 ,  A61B5/4082 ,  A61N1/0534 ,  A61N1/36067

Abstract: Systems and methods are disclosed to detect and/or classify electrophysiological signals as motor events. In some embodiments, a method may include: recording a first plurality of electrophysiological signals from a first plurality of probes inserted into the left hemisphere of the brain; recording a second plurality of electrophysiological signals from a second plurality of probes inserted into the right hemisphere of the brain; pre-processing the first plurality of electrophysiological signals and the second plurality of electrophysiological signals; bipolar re-referencing the first plurality of electrophysiological signals and the second plurality of electrophysiological signals; determining an optimal pair of electrophysiological signals from the bipolar re-referenced first plurality of electrophysiological signals and the bipolar re-referenced second plurality of electrophysiological signals; matching the optimal pair of electrophysiological signals with a template; and detecting motor events from the matching.

公开(公告)号：US20160047728A1

公开(公告)日：2016-02-18

申请号：US14777374

申请日：2014-03-14

Applicant: COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER

Inventor： James C. Wilson ,  Siavash Pourkamali Anaraki

IPC: G01N15/02 ,  G01H11/08 ,  G01N15/06

CPC classification number: G01N15/0255 ,  G01H11/08 ,  G01N1/22 ,  G01N15/06 ,  G01N2015/0046 ,  G01N2015/0261

Abstract: Embodiments of the invention include aerosol impactors comprising one or more micromechanical resonators. Impactors according to embodiments of the invention can provide size classification and/or concentration of aerosol particulate. Aerosol impactors can use an air flow device, such as a pump, to create a constant flow of air. Nozzles of varying diameters are used to separate particulate of varying sizes and the particles that pass through strike a measuring device. MEMS resonators can be integrated into arrays to provide mass sensitivity in a small, lightweight and cost effective package, which will effectively allow for the measurement of the mass of every micro/nanoscale particle landing on the surface.

Abstract translation: 本发明的实施例包括包括一个或多个微机械谐振器的气溶胶冲击器。 根据本发明的实施方案的冲击器可以提供气溶胶颗粒的尺寸分类和/或浓度。 气溶胶冲击器可以使用诸如泵的空气流动装置来产生恒定的空气流。 使用不同直径的喷嘴分离不同尺寸的颗粒，并且通过的颗粒撞击测量装置。 MEMS谐振器可以集成到阵列中，以在小型，轻便和成本有效的封装中提供质量灵敏度，这将有效地允许测量表面上每个微/纳米级粒子的质量。

公开(公告)号：US20140050761A1

公开(公告)日：2014-02-20

申请号：US13829105

申请日：2013-03-14

Applicant: Colorado Seminary, which owns and Operates The University of Denver

Inventor： Eric Bergeron ,  Scott Dusan Pegan ,  Stuart T. Nichol ,  Michelle Kay Deaton

IPC: A61K39/12

CPC classification number: A61K39/12 ,  A61K2039/5254 ,  C12N2760/12034 ,  Y02A50/397

Abstract: The genetically modified hemorrhagic fever virus of this invention possesses a viral ovarian tumor protease with decreased ability to remove ubiquitin (Ub) and ISG15 tags that the human organism uses to label proteins for removal. Unlike complete knockout strains, the modified virus retains enough activity for replication in a human cell line. This creates an immunogenic and non-pathogenic virus that can be used as an effective live vaccine agent.

Abstract translation: 本发明的遗传修饰出血热病毒具有病毒性卵巢肿瘤蛋白酶，其具有降低人类生物体用于标记蛋白质去除的泛素（Ub）和ISG15标签的能力降低的能力。 与完全敲除菌株不同，经修饰的病毒在人细胞系中保留足够的活性用于复制。 这产生可用作有效活疫苗剂的免疫原性和非致病性病毒。