A disc brake, preferably a compressed air-actuated disc brake, in particular for a motor vehicle, has a brake application mechanism with a brake rotary lever, at least one spindle unit having a threaded rod screwed into a bridge, and a brake caliper. The caliper frames an edge region of a brake disc. The brake caliper has a brake application portion and a caliper back which are connected together via tie bars. The brake application mechanism with the brake rotary lever is received in the brake application portion of the brake caliper from an application face side of the brake disc. The brake application portion of the brake caliper has a first region, in which the application mechanism and a force transmission portion of the brake rotary lever are arranged, a second region, which is formed as a lever housing, and a lever portion for the brake rotary lever. A support wall with a bearing portion, which forms a pivot bearing with a brake rotary lever axis that runs parallel to the brake disc, for the brake rotary lever is arranged between the first region and the second region.