An example method for adaptively coalescing remote direct memory access (RDMA) acknowledgements is provided. The method includes determining one or more input/output (I/O) characteristics of RDMA packets of a plurality of queue pairs (QPs) on a per-QP basis, each QP identifying a respective RDMA connection between a respective first compute node and a respective second compute node. The method further includes determining an acknowledgement frequency for providing acknowledgements of the RDMA packets on a per-QP basis (i.e., a respective acknowledgement frequency is set for each QP) based on the determined one or more I/O characteristics for each QP.