Disclosed are a method for transmitting multi-user uplink data in a wireless communication system and an apparatus therefore. In detail, a method for transmitting multi-user uplink data in a wireless communication system includes: receiving, by a station (STA), a UL MU scheduling frame for initiating uplink multi-user (UL MU) transmission from an access point (AP); transmitting, by the STA, a UL MU data frame to the AP through a frequency band or a stream allocated by the UL MU scheduling frame; and receiving, by the STA, an acknowledge (ACK) frame from the AP in response to the UL MU data frame, wherein the UL MU scheduling frame may include protection duration information for protecting a UL MU procedure.