Invention Application
- Patent Title: POLYPEPTIDES, CELLS, AND METHODS INVOLVING ENGINEERED CD16
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Application No.: US15300024Application Date: 2015-03-27
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Publication No.: US20170174743A1Publication Date: 2017-06-22
- Inventor: Bruce Kenneth Walcheck , Dan Samuel Kaufman , Jianming Wu , Yawu Jing , Zhenya Li
- Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
- International Application: PCT/US2015/022998 WO 20150327
- Main IPC: C07K14/735
- IPC: C07K14/735 ; A61K38/17 ; C12N5/0786 ; A61K39/395 ; C12N5/0783 ; C12N5/0787 ; A61K35/17 ; C07K16/32
Abstract:
This disclosure describes, generally, a modified form of CD 16, genetically-modified cells that express the modified CD 16, and methods that involve the genetically-modified cells. The modified form of CD 16 can exhibit increased anti-tumor and/or anti- viral activity due, at least in part, to reduced susceptibility to ADAM17-mediated shedding upon NK cell stimulation.
Public/Granted literature
- US10464989B2 Polypeptides, cells, and methods involving engineered CD16 Public/Granted day:2019-11-05
Information query
