- 专利标题: INHIBITORS OF BRUTON'S TYROSINE KINASE
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申请号: US15454452申请日: 2017-03-09
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公开(公告)号: US20170183327A1公开(公告)日: 2017-06-29
- 发明人: Francisco Javier Lopez-Tapia , Sung-Sau So , Qi Qiao , Romyr Dominique
- 申请人: Hoffmann-La Roche Inc. , Chugai Pharmaceutical Inc.
- 主分类号: C07D403/06
- IPC分类号: C07D403/06 ; C07D403/14 ; C07D401/14 ; C07D409/14
摘要:
This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
公开/授权文献
- US10093657B2 Inhibitors of bruton's tyrosine kinase 公开/授权日:2018-10-09
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