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公开(公告)号：US20200207741A1
公开(公告)日：2020-07-02
申请号：US16815443
申请日：2020-03-11
IPC分类号： C07D403/06 , C07D409/14 , C07D403/14 , C07D401/14
摘要： This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases onused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
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公开(公告)号：US10093657B2
公开(公告)日：2018-10-09
申请号：US15454452
申请日：2017-03-09
IPC分类号： C07D403/06 , C07D403/14 , C07D401/14 , C07D409/14
摘要： This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
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公开(公告)号：US20170183327A1
公开(公告)日：2017-06-29
申请号：US15454452
申请日：2017-03-09
IPC分类号： C07D403/06 , C07D403/14 , C07D401/14 , C07D409/14
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D409/14
摘要： This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
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公开(公告)号：US20180305340A1
公开(公告)日：2018-10-25
申请号：US16018683
申请日：2018-06-26
IPC分类号： C07D403/06 , C07D409/14 , C07D401/14 , C07D403/14
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D409/14
摘要： This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
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