- 专利标题： Methods for Top-Down Multiplexed Mass Spectral Analysis of Mixtures of Proteins or Polypeptides
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申请号： US15406626申请日： 2017-01-13
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公开(公告)号： US20170205425A1公开(公告)日： 2017-07-20
- 发明人: Ping F. YIP , James L. STEPHENSON, JR. , John E. P. SYKA
- 申请人： Thermo Finnigan LLC
- 专利权人： Thermo Finnigan LLC
- 当前专利权人： Thermo Finnigan LLC
- 主分类号： G01N33/68
- IPC分类号： G01N33/68
摘要：
Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (PTR) and real-time data analysis methods are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kDa by removing charge and reducing the collisional cross section.
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