- 专利标题： IMPROVED FACTOR VIII PREPARATIONS SUITABLE FOR THERAPEUTIC USE AND PROCESSES TO OBTAIN THESE
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申请号： US15328420申请日： 2015-07-24
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公开(公告)号： US20170209546A1公开(公告)日： 2017-07-27
- 发明人: Stefan SCHMIDBAUER , Hubert METZNER , Lars ROBBEL
- 申请人： CSL BEHRING GMBH
- 申请人地址： DE Marburg
- 专利权人： CSL BEHRING GMBH
- 当前专利权人： CSL BEHRING GMBH
- 当前专利权人地址： DE Marburg
- 优先权： EP14178563.4 20140725
- 国际申请： PCT/EP2015/067014 WO 20150724
- 主分类号： A61K38/37
- IPC分类号： A61K38/37 ; G01N33/68
摘要：
The present invention relates to pharmaceutical preparations comprising two-chain Factor VIII that are essentially free of Factor VIII-Light Chains (FVIII-LCs) which are not associated with Factor VIII-Heavy Chains (FVIII-HCs) having higher purity and which are less immunogenic. The invention also relates to methods to test the suitability of a pharmaceutical Factor VIII preparation and to methods to reduce in pharmaceutical Factor VIII preparations the amount of FVIII-HCs which are not associated with FVIII-LCs and/or of FVIII-LCs which are not associated with FVIII-HCs.
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