专利检索 ap:("CSL BEHRING GMBH") AND inv:"Lars ROBBEL" 第 1 页

1.

发明申请
IMPROVED FACTOR VIII PREPARATIONS SUITABLE FOR THERAPEUTIC USE AND PROCESSES TO OBTAIN THESE 审中-公开

公开(公告)号：US20170209546A1

公开(公告)日：2017-07-27

申请号：US15328420

申请日：2015-07-24

申请人： CSL BEHRING GMBH

发明人： Stefan SCHMIDBAUER , Hubert METZNER , Lars ROBBEL

IPC分类号： A61K38/37 , G01N33/68

CPC分类号： A61K38/37 , G01N33/15 , G01N33/68 , G01N2333/755

摘要： The present invention relates to pharmaceutical preparations comprising two-chain Factor VIII that are essentially free of Factor VIII-Light Chains (FVIII-LCs) which are not associated with Factor VIII-Heavy Chains (FVIII-HCs) having higher purity and which are less immunogenic. The invention also relates to methods to test the suitability of a pharmaceutical Factor VIII preparation and to methods to reduce in pharmaceutical Factor VIII preparations the amount of FVIII-HCs which are not associated with FVIII-LCs and/or of FVIII-LCs which are not associated with FVIII-HCs.