- 专利标题： MONOCYCLIC ISOXAZOLINES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN
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申请号： US15329284申请日： 2015-07-24
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公开(公告)号： US20170210715A1公开(公告)日： 2017-07-27
- 发明人: Pengcheng Patrick Shao , Feng Ye , Petr Vachal , Jayanth Thiruveliore Thatal
- 申请人： Pengcheng Patrick Shao , Feng Ye , Petr Vachal , Jayanth Thiruveliore Thatal , Merck Sharp & Dohme Corp.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US15/41871 WO 20150724
- 主分类号： C07D261/04
- IPC分类号： C07D261/04 ; A61K31/397 ; A61K31/42 ; A61K31/444 ; A61K31/4245 ; A61K31/4439 ; C07D413/14 ; A61K45/06 ; C07D413/10
摘要：
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein D1, D2 and D3 are each N, CH, or substituted CH, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.
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