发明申请
- 专利标题： ANTI-TRKA ANTIBODIES WITH ENHANCED INHIBITORY PROPERTIES AND DERIVATIVES THEREOF
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申请号： US15265331申请日： 2016-09-14
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公开(公告)号： US20170218087A1公开(公告)日： 2017-08-03
- 发明人: Stanislas BLEIN , Romain Ollier , Darko Skegro
- 申请人： GLENMARK PHARMACEUTICALS S.A.
- 申请人地址： CH La Chaux-de-Fonds
- 专利权人： GLENMARK PHARMACEUTICALS S.A.
- 当前专利权人： GLENMARK PHARMACEUTICALS S.A.
- 当前专利权人地址： CH La Chaux-de-Fonds
- 主分类号： C07K16/40
- IPC分类号： C07K16/40
摘要：
The present invention relates to antibodies directed against TrkA receptor and their uses, including humanized anti-TrkA antibodies. More specifically, the present invention relates to humanized anti-TrkA antibodies with enhanced inhibitory properties comprising a heavy chain variable region, a light chain variable region, a human light chain constant region and a variant human IgG4 heavy chain constant region which exhibit altered exchange properties.
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