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公开(公告)号：US10758517B2
公开(公告)日：2020-09-01
申请号：US16282125
申请日：2019-02-21
发明人： Monika Tandon , Sumit Sant , Neelima Khairatkar-Joshi , Girish Gudi , Vinu C. A. Menon , Ravi Talluri
IPC分类号： A61K31/4196 , A61P19/02 , A61K9/16 , A61K9/00 , A61K9/14
摘要： The present invention relates to a microsomal prostaglandin E synthases-1 (“mPGES-1”) inhibitor for the treatment of osteoarthritis pain in a subject. For example, the present invention relates to a method of treating moderate osteoarthritis pain in a subject in need thereof by orally administering to the subject a substituted triazolone compound as a mPGES-1 inhibitor. The present invention also relates to pharmaceutical compositions comprising the mPGES-1 inhibitor, and to processes for preparing such pharmaceutical compositions.
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公开(公告)号：US20200061190A1
公开(公告)日：2020-02-27
申请号：US16504411
申请日：2019-07-08
摘要： A pharmaceutical formulation is described comprising a therapeutically effective amount of an antibody, an acetate buffer, a lyoprotectant, a bulking agent and a surfactant.
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公开(公告)号：US10457649B2
公开(公告)日：2019-10-29
申请号：US16119306
申请日：2018-08-31
发明人： Nagarajan Muthukaman , Laxmikant A. Gharat , Suresh M. Kadam , Sachin Gavhane , Sandeep B. Khandagale , Sunil P. Nirgude
IPC分类号： C07D249/12 , A61P29/00 , G01N23/20 , G01N21/35
摘要： The present application relates to solid state forms of a triazolone compound which exhibit mPGES-1 enzyme inhibition activity, specifically N-(4-chloro-3-(5-oxo-1-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)benzyl)pivalamide (Compound of formula II), and process for preparation thereof.
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公开(公告)号：US10391083B2
公开(公告)日：2019-08-27
申请号：US15919460
申请日：2018-03-13
IPC分类号： C07D249/12 , A61K31/4196 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/4439 , A61K31/5377 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/12 , A61K31/422
摘要： The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.
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公开(公告)号：US10336688B2
公开(公告)日：2019-07-02
申请号：US16204977
申请日：2018-11-29
发明人： Sanjib Das , Laxmikant A. Gharat , Rajendra L. Harde , Dnyaneshwar E. Shelke , Shailesh R. Pardeshi , Abraham Thomas , Neelima Khairatkar-Joshi , Daisy M. Shah , Malini Bajpai
IPC分类号： C07C237/42 , A61P11/14 , A61P11/08 , A61P17/06 , A61P11/06
摘要： The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
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公开(公告)号：US10189775B2
公开(公告)日：2019-01-29
申请号：US15754037
申请日：2016-08-26
发明人： Sanjib Das , Laxmikant A. Gharat , Rajendra L. Harde , Dnyaneshwar E. Shelke , Shailesh R. Pardeshi , Abraham Thomas , Neelima Khairatkar-Joshi , Daisy M. Shah , Malini Bajpai
IPC分类号： C07C237/42 , A61P11/06 , A61P11/08 , A61P11/14 , A61P17/06
摘要： The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
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公开(公告)号：US20170274147A1
公开(公告)日：2017-09-28
申请号：US15177697
申请日：2016-06-09
IPC分类号： A61M5/315
CPC分类号： A61M5/31548 , A23K40/00 , A61M5/3129 , A61M5/31505 , A61M5/31536 , A61M5/31553 , A61M5/31555 , A61M5/3156 , A61M5/31563 , A61M5/31565 , A61M5/31591 , A61M2005/3104 , A61M2005/311 , A61M2005/3125 , A61M2205/583 , A61M2250/00
摘要： Disclosed herein is a syringe device comprises (a) an outer housing, (b) a barrel, (c) a stopper, and (d) a plunger with one or more grooves.
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公开(公告)号：US20170233380A1
公开(公告)日：2017-08-17
申请号：US15318513
申请日：2016-08-02
发明人： Sanjib DAS , Laxmikant A. GHARAT , Rajendra L. HARDE , Sandeep Y. SHELKE , Shailesh R. PARDESHI , Abraham THOMAS , Neelima KHAIRATKAR-JOSHI , Daisy M. SHAH , Malini BAJPAI
IPC分类号： C07D417/12 , C07D213/40 , C07D401/04 , C07D231/12 , C07D413/12 , C07D413/04 , C07D241/12 , C07D241/20 , C07D241/18 , C07D405/14 , C07D239/26 , C07D239/36
CPC分类号： C07D417/12 , C07D213/40 , C07D231/12 , C07D239/26 , C07D239/36 , C07D239/42 , C07D241/12 , C07D241/18 , C07D241/20 , C07D401/04 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/12
摘要： The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
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公开(公告)号：US20170218087A1
公开(公告)日：2017-08-03
申请号：US15265331
申请日：2016-09-14
发明人： Stanislas BLEIN , Romain Ollier , Darko Skegro
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to antibodies directed against TrkA receptor and their uses, including humanized anti-TrkA antibodies. More specifically, the present invention relates to humanized anti-TrkA antibodies with enhanced inhibitory properties comprising a heavy chain variable region, a light chain variable region, a human light chain constant region and a variant human IgG4 heavy chain constant region which exhibit altered exchange properties.
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公开(公告)号：US20170145115A1
公开(公告)日：2017-05-25
申请号：US15190268
申请日：2016-06-23
发明人： Stanislas BLEIN , Romain Ollier , Darko Skegro , Samuel Hou
CPC分类号： C07K16/468 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/71 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention describes novel hetero-dimeric immunoglobulins or fragments thereof which bind to CD3 and a disease associated antigen. These hetero-dimeric immunoglobulins have been engineered to promote hetero-dimer formation during expression and can be purified to a high degree using a Protein A differential purification technique.
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