A variable valve mechanism of an internal combustion engine includes a cam, a transmission mechanism, a first variable device that controls the transmission mechanism to continuously change at least a maximum lift amount of a lift curve indicating a lift amount of a valve that corresponds to a rotation angle of the internal combustion engine, and a second variable device that controls the transmission mechanism to continuously change at least an operation angle of the lift curve. When the lift curve lies in any condition within a predetermined range that covers all or part of a variable range of the lift curve, an absolute value of a ratio of a maximum lift amount variation to an operation angle variation for a slight change from the condition caused by the first variable device is larger than that for a slight change from the condition caused by the second variable device.