发明申请
- 专利标题: METHOD AND APPARATUS FOR GENERATION OF MICROPARTICLES CONTAINING IMMOBILIZED ENZYME
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申请号: US15326519申请日: 2015-07-23
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公开(公告)号: US20170226500A1公开(公告)日: 2017-08-10
- 发明人: Otto Fuerst , Herbert Harttig , Bernd Hiller
- 申请人: Roche Diabetes Care, Inc.
- 申请人地址: US IN Indianapolis
- 专利权人: Roche Diabetes Care, Inc.
- 当前专利权人: Roche Diabetes Care, Inc.
- 当前专利权人地址: US IN Indianapolis
- 优先权: EP14178121.1 20140723
- 国际申请: PCT/EP2015/066936 WO 20150723
- 主分类号: C12N11/10
- IPC分类号: C12N11/10 ; C12N9/04 ; C12Q1/00 ; C12Q1/54
摘要:
The invention concerns a method and an apparatus for generation of micropartides containing an immobilized functional component, where the following measures are proposed: —spraying a liquid (32) containing a soluble alginate and a functional component consisting of molecules or nanoparticles to generate a stream (60) of droplets, —directing the stream (60) of droplets onto a precipitation bath (16) and capturing the droplets therein by application of high voltage (14), —precipitating the droplets in the precipitation bath (16) by means of a precipitation liquid (18) containing an alginate complexing agent, such that the droplets are solidified to form micropartides (10) containing the functional component and —extracting the micropartides (10) from the precipitation bath (16).