公开(公告)号：US20220403430A1

公开(公告)日：2022-12-22

申请号：US17772693

申请日：2020-10-30

申请人： SAMYANG CORPORATION

发明人： Soun Gyu KWON ,  Bu-Soo PARK ,  Sanghee LEE ,  Jin-Ha KIM ,  Sin Hye AHN ,  Eunsoo CHOI

IPC分类号： C12P19/02 ,  C12N9/90 ,  C12N1/20 ,  C12N11/10

摘要： The present disclosure relates to cell immobilized beads and a method for preparing the same and, more specifically, to cell-immobilized beads wherein the conversion activity of cells contained in the immobilized beads is excellent and wherein the conversion activity is maintained even during distribution and storage processes, a method for preparing the cell-immobilized beads, and a use of the conversion activity of the beads.

公开(公告)号：US11473053B2

公开(公告)日：2022-10-18

申请号：US16669650

申请日：2019-10-31

申请人： PLASTICELL LIMITED

发明人： Marina Tarunina ,  Cedric Humbert ,  Shahzad Ali ,  Yen Choo ,  Aaron Tsu Tshen Chuang ,  Dennis Saw

IPC分类号： C12N5/00 ,  C12N5/078 ,  C12N11/10

摘要： A hydrogel capsule comprising a stem cell core that has been induced to differentiate into a hematopoietic lineage cell, and methods for the production of hematopoietic lineage cells from stem cells encapsulated in a hydrogel.

公开(公告)号：US11447766B2

公开(公告)日：2022-09-20

申请号：US16064644

申请日：2016-12-21

申请人： Daesang Corporation

发明人： Baek Joong Kim ,  Tae Gun Kim ,  Min Su Kim ,  Tae Yong Kim ,  Eun Bum Song

IPC分类号： C12M1/00 ,  C12N11/00 ,  C12N11/10 ,  C12N9/90 ,  C12M1/12 ,  C12M1/26 ,  C12M1/02 ,  C12M1/04 ,  C12N15/77 ,  C12M1/40

摘要： An embodiment of the present disclosure provides an apparatus for immobilizing a microbial cell, the apparatus including: a mixing tank in which a cell-carrier-containing mixed solution is accommodated; a nozzle part through which the cell-carrier-containing mixed solution is injected from the mixing tank and is discharged to the outside; and a reaction tank in which a cell immobilized bead is formed by contact between the cell-carrier-containing mixed solution discharged from the nozzle part and an aqueous curing agent solution. In the apparatus for immobilizing a microbial cell according to the present disclosure, since the cell-carrier-containing mixed solution is injected through an air spraying nozzle, even when an immobilized carrier solution having a high viscosity is used, a microbial cell immobilized bead having a small size and having a spherical shape, or an almost spherical shape may be mass-produced.

公开(公告)号：US20210163917A1

公开(公告)日：2021-06-03

申请号：US17116978

申请日：2020-12-09

申请人： Battelle Memorial Institute

发明人： Katarzyna Hanna Kucharzyk ,  Ramanathan Lalgudi

IPC分类号： C12N11/04 ,  B09C1/10 ,  C12N11/10

摘要： An enzyme formulation includes an encapsulated fungal enzyme which is effective for degrading at least one material selected from the group consisting of hydrocarbons, vulcanized rubber, synthetic rubber, natural rubber, vulcanized polymers and perfluorinated compounds. A degradation method includes treating one of the above-mentioned materials with an encapsulated fungal enzyme to degrade the material.

公开(公告)号：US10995349B2

公开(公告)日：2021-05-04

申请号：US16913761

申请日：2020-06-26

申请人： Codexis, Inc.

发明人： Haibin Chen ,  Yong Koy Bong ,  Fabien L. Cabirol ,  Anupam Gohel Prafulchandra ,  Tao Li ,  Jeffrey C. Moore ,  Martina Quintanar-Audelo ,  Yang Hong ,  Steven J. Collier ,  Derek Smith

IPC分类号： C12N11/10 ,  C12P17/12 ,  C12P17/18 ,  C12N9/02 ,  C12P13/24 ,  C12P13/04

摘要： The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

公开(公告)号：US20210040470A1

公开(公告)日：2021-02-11

申请号：US16979695

申请日：2019-04-10

申请人： SINGAPORE HEALTH SERVICES PTE LTD

发明人： Ngian Chye Tan ,  Christopher Hoe Kong Chui ,  Zanzan Zhu ,  Wai Chye Cheong ,  Fiona Wei Ling Loke ,  John Shen Him Ng ,  Lu Gan ,  Richard Siang-Long Lieu

IPC分类号： C12N11/10 ,  C12N11/06 ,  C08L5/08 ,  C08L79/02 ,  G01N27/327

摘要： The present invention relates to an enzyme-containing polymer of 2-amino monosaccharide, preferably an enzyme-containing chitosan, comprising: a first repeating unit of the following Formula 1a: a second repeating unit of the following Formula 1b: and a third repeating unit of the following Formula 1c: or conjugate salts thereof, wherein all the substituents are as defined herein. There is also provided a redox polymer and the methods of preparing the enzyme-containing polymer and the redox polymer. The present invention also relates to a sensor, a method of manufacturing the sensor, a monitor, methods for monitoring failure of a tissue and uses of the sensor comprising the enzyme-containing polymer, and the monitor thereof.

公开(公告)号：US20190078072A1

公开(公告)日：2019-03-14

申请号：US15917014

申请日：2018-03-09

申请人： Guild Associates, Inc.

发明人： Augustine A. DiNovo ,  Dominic DiNovo ,  David A. Schofield ,  Matthew F. Smiechowski ,  Francis H. Verhoff

IPC分类号： C12N11/10 ,  C12N11/02 ,  C12N11/12 ,  C12N11/06

摘要： The present application discloses immobilized enzymes and immobilized enzyme materials comprising a crosslinked enzyme having a support material which includes a biomass material different than the biomass used to initially derive the enzyme. Optionally, the immobilized enzyme further includes a polymeric material and/or the biomass which was used to initially derive the enzyme. The resulting immobilized enzyme materials may be biodegradable. The present application also discloses methods of making and using the disclosed immobilized enzyme materials.

公开(公告)号：US20190010483A1

公开(公告)日：2019-01-10

申请号：US16137925

申请日：2018-09-21

申请人： INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

发明人： Pei-Yi TSAI ,  Chih-Hung CHEN ,  Yi-Hung LIN ,  Chih-Chieh HUANG ,  Hsin-Hsin SHEN ,  Liang-Yin KE ,  Chu-Huang CHEN

IPC分类号： C12N11/12 ,  C12N11/14 ,  C12N11/10 ,  A61M1/34 ,  C12M1/00

摘要： A method for ex vivo treating blood or plasma is provided. The method includes (a) ex vivo contacting a blood or plasma with an enzyme composition to react the enzyme composition with the blood or plasma, wherein the enzyme composition is capable of eliminating electronegative low-density lipoprotein from the blood or plasma by the activity of the enzyme composition, and the enzyme composition is selected from a group consisting of: a first enzyme for eliminating a glycan residue of an electronegative low-density lipoprotein (LDL); a second enzyme for eliminating ceramide carried by a electronegative low-density lipoprotein (LDL); and a combination thereof; and (b) terminating contact between the blood or plasma and the enzyme composition to terminate the reaction of the enzyme composition with the blood or plasma.

公开(公告)号：US10131961B2

公开(公告)日：2018-11-20

申请号：US14433323

申请日：2013-10-09

申请人： BIOSIGMA S.A.

发明人： Patricio Ernesto Martinez Bellange ,  Pilar Angelica Parada Valdecantos

IPC分类号： C12N1/20 ,  C21B15/00 ,  C12P3/00 ,  C12P39/00 ,  C12N11/04 ,  C22B3/18 ,  C12N11/10

摘要： The invention refers to viable biomining microorganisms encapsulated in alginate capsules, called BioSigma Bioleaching Seeds or BBS, wherein the alginate capsules have iron (II) and/or iron (III) ions as the cross-linking cations, and the usage of these capsules in the inoculation of these microorganisms in bioleaching processes.

公开(公告)号：US10105681B2

公开(公告)日：2018-10-23

申请号：US14773024

申请日：2014-03-13

申请人： RAN Biotechnologies, Inc.

发明人： Roger A. Nassar

IPC分类号： C07K1/22 ,  C12N7/02 ,  B01J20/24 ,  C12N11/10 ,  A61M1/36 ,  C12N11/02 ,  C12N11/06 ,  C12N11/08 ,  C12N11/14 ,  B01J20/26 ,  C12N7/00 ,  C02F3/10

摘要： Material complexes that capture biologicals and methods of synthesizing and using such complexes composed of fluid-insoluble material and a receptor are provided herewith. The fluid-insoluble material has reactive functionality on its surface, including hydroxyl, amino, mercapto or epoxy functionality material. The material can be agarose, sand, textile, or any combination thereof. The receptor is selected from the group consisting of mono- and poly-saccharides, heparin, or any combination thereof. Also provided are methods whereby releasing the captured biologicals is controllable.