Invention Application
- Patent Title: COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS
-
Application No.: US15606740Application Date: 2017-05-26
-
Publication No.: US20170260192A1Publication Date: 2017-09-14
- Inventor: Kevin Frankowski , Samarjit Patnaik , Sui Huang , Juan Jose Marugan , John Norton , Frank J. Schoenen , Noel Terrence Southall , Steven Titus , Wei Zheng
- Applicant: The United States of America, as represented by the Secretary, Dept of Health and Human Services , University of Kansas , Northwestern University
- Applicant Address: US MD Bethesda US KS Lawrence US IL Evanston
- Assignee: The United States of America, as represented by the Secretary, Dept of Health and Human Services,University of Kansas,Northwestern University
- Current Assignee: The United States of America, as represented by the Secretary, Dept of Health and Human Services,University of Kansas,Northwestern University
- Current Assignee Address: US MD Bethesda US KS Lawrence US IL Evanston
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07F7/18 ; A61K45/06 ; A61K31/519 ; A61K31/695
Abstract:
The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.
Public/Granted literature
- US10301314B2 Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis Public/Granted day:2019-05-28
Information query
