发明申请
- 专利标题: HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF
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申请号: US15309741申请日: 2015-05-11
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公开(公告)号: US20170266119A1公开(公告)日: 2017-09-21
- 发明人: Yang Deng , Asiri Ediriwickrema , William M. Saltzman
- 申请人: Yale University
- 国际申请: PCT/US15/30169 WO 20150511
- 主分类号: A61K9/50
- IPC分类号: A61K9/50 ; A61K31/4745 ; A61K9/00 ; A61K31/427 ; A61K47/34 ; A61K9/51
摘要:
Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.