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    TOPICAL FORMULATION OF HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES THEREOF
    1.
    发明申请
    TOPICAL FORMULATION OF HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES THEREOF 审中-公开

    公开(公告)号：US20200000687A1

    公开(公告)日：2020-01-02

    申请号：US16379224

    申请日：2019-04-09

    申请人： Yale University

    发明人： Yang Deng ,  Asiri Ediriwickrema ,  William M. Saltzman

    IPC分类号： A61K8/02 ,  C08G83/00 ,  C07C59/06 ,  C07C59/08 ,  A61K31/4178 ,  A61K9/00 ,  A61K9/50 ,  A61K9/16 ,  A61K31/427 ,  A61K9/51 ,  A61K31/4745 ,  A61K47/34 ,  A61K8/90 ,  A61Q17/04

    摘要： Core-shell particles have a hydrophobic core and a shell formed of or containing hyperbranched polyglycerol (HPG). The HPG can be covalently bound to the one or more materials that form the core or coated thereon. The HPG coating can be modified to adjust the properties of the particles. For example, unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption. Alternatively, the hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups on tissue or otherwise interact with tissue to adhere the particles to the tissue, cells, or extracellular materials, such as proteins. Such functional groups include, but not limited to, aldehydes, amines, and O-substituted oximes. Topical formulation for application to the skin contain these HPG coated nanoparticles. In some embodiments, the particles include therapeutic, diagnostic, nutraceutical, and/or prophylactic agents such as those used as sunblock compositions.

    HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF
    3.
    发明申请
    HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF 审中-公开
    高分子聚合物包覆颗粒及其制备和使用方法

    公开(公告)号：US20170000737A1

    公开(公告)日：2017-01-05

    申请号：US15269456

    申请日：2016-09-19

    申请人： Yale University

    发明人： Yang Deng ,  Asiri Ediriwickrema ,  William M. Saltzman

    IPC分类号： A61K9/16 ,  A61K31/427

    摘要： Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

    摘要翻译： 本文描述了核 - 壳颗粒及其制备和使用方法。 核心由或含有一种或多种疏水性材料或更多疏水性材料形成或包含。 外壳由超支化聚甘油（HPG）形成或含有。 可以修改HPG涂层以调整颗粒的性质。 未改性的HPG涂层赋予了抵抗非特异性蛋白质吸收和增加血液循环的颗粒的隐形性能。 HPG涂层上的羟基可以被化学修饰以形成与官能团反应并将颗粒粘附到组织，细胞或细胞外物质如蛋白质上的官能团。

    Topical formulation of hyperbranched polyglycerol-coated particles thereof
    4.
    发明授权
    Topical formulation of hyperbranched polyglycerol-coated particles thereof 有权

    公开(公告)号：US10272019B2

    公开(公告)日：2019-04-30

    申请号：US15309733

    申请日：2015-05-11

    申请人： Yale University

    发明人： Yang Deng ,  Asiri Ediriwickrema ,  William M. Saltzman

    IPC分类号： A61K8/02 ,  C08G83/00 ,  C07C59/06 ,  C07C59/08 ,  A61K9/50 ,  A61K31/4178 ,  A61K9/16 ,  A61K31/427 ,  A61K9/00 ,  A61K9/51 ,  A61K31/4745 ,  A61K47/34 ,  A61K8/90 ,  A61Q17/04

    摘要： Core-shell particles have a hydrophobic core and a shell formed of or containing hyperbranched polyglycerol (HPG). The HPG can be covalently bound to the one or more materials that form the core or coated thereon. The HPG coating can be modified to adjust the properties of the particles. For example, unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption. Alternatively, the hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups on tissue or otherwise interact with tissue to adhere the particles to the tissue, cells, or extracellular materials, such as proteins. Such functional groups include, but not limited to, aldehydes, amines, and O-substituted oximes. Topical formulation for application to the skin contain these HPG coated nanoparticles. In some embodiments, the particles include therapeutic, diagnostic, nutraceutical, and/or prophylactic agents such as those used as sunblock compositions.

    Topical formulation of hyperbranched polyglycerol-coated particles thereof
    7.
    发明授权
    Topical formulation of hyperbranched polyglycerol-coated particles thereof 有权

    公开(公告)号：US10758459B2

    公开(公告)日：2020-09-01

    申请号：US16379224

    申请日：2019-04-09

    申请人： Yale University

    发明人： Yang Deng ,  Asiri Ediriwickrema ,  William M. Saltzman

    IPC分类号： A61K8/02 ,  C08G83/00 ,  C07C59/06 ,  C07C59/08 ,  A61K31/4178 ,  A61K9/00 ,  A61K9/50 ,  A61K9/16 ,  A61K31/427 ,  A61K9/51 ,  A61K31/4745 ,  A61K47/34 ,  A61K8/90 ,  A61Q17/04

    摘要： Core-shell particles have a hydrophobic core and a shell formed of or containing hyperbranched polyglycerol (HPG). The HPG can be covalently bound to the one or more materials that form the core or coated thereon. The HPG coating can be modified to adjust the properties of the particles. For example, unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption. Alternatively, the hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups on tissue or otherwise interact with tissue to adhere the particles to the tissue, cells, or extracellular materials, such as proteins. Such functional groups include, but not limited to, aldehydes, amines, and O-substituted oximes. Topical formulation for application to the skin contain these HPG coated nanoparticles. In some embodiments, the particles include therapeutic, diagnostic, nutraceutical, and/or prophylactic agents such as those used as sunblock compositions.