A method of resistance spot welding an aluminum workpiece and an adjacent overlapping steel workpiece is disclosed in which a source of a reactive metal in a diffusible state is located along a faying interface of an aluminum workpiece and an adjacent overlapping steel workpiece. The source of the reactive metal in a diffusible state may take on a variety of forms including (1) a composite adhesive layer that includes reactive particles dispersed throughout a structural thermosetting adhesive matrix or (1) a reactive alloy layer that confronts and is in proximate contact with a faying surface of the aluminum workpiece. Once the source of a reactive material in a diffusible state is in place and the workpiece stack-up is assembled, an electrical current is passed through the workpiece stack-up and between a set of opposed welding electrodes at a weld zone to ultimately produce a weld joint.