- 专利标题： AN IMPROVED PROCESS FOR THE PREPARATION OF ENZALUTAMIDE
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申请号： US15516206申请日： 2015-10-01
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公开(公告)号： US20170313662A1公开(公告)日： 2017-11-02
- 发明人: Kameswar Rao Chivukula , Veera Karuturi , Rao Venkateswara , Srinivas Benda , Ramachandra Anke , Dharmapuri Gajula , Venkata Rama Krishna Murt Moturu , Venkata Sunil Kumar Indukuri , Seeta Rama Anjaneyulu Gorantla , Satyanarayana Chava
- 申请人： Laurus Labs Private Limited
- 优先权： IN4958/CHE/2014 20141001; IN6304/CHE/2014 20141215
- 国际申请： PCT/IN2015/000375 WO 20151001
- 主分类号： C07D233/86
- IPC分类号： C07D233/86 ; C07C25/13 ; C07C22/08 ; C07C331/28 ; C07C255/49 ; C07C2601/16
摘要：
The present invention relates to an improved process for the preparation of enzalutamide by conventional synthesis, which avoids utilization of microwave irradiation and noxious reagents. The present invention also relates to an improved process for preparation of 4-isothiocyanato-2-(trifluoromethyl) benzonitrile, which is an intermediate in the synthesis of Enzalutamide.
公开/授权文献
- US10131636B2 Process for the preparation of Enzalutamide 公开/授权日：2018-11-20
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