公开(公告)号：US20170369408A1

公开(公告)日：2017-12-28

申请号：US15482451

申请日：2017-04-07

申请人： NeOnc Technologies, Inc.

发明人： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPALLI

IPC分类号： C07C33/14 ,  C07D231/12 ,  A61K47/54 ,  C07D207/26 ,  C07B59/00 ,  A61K45/06 ,  A61K31/495 ,  A61K31/4188 ,  A61K31/415 ,  A61K31/4015 ,  A61K31/045 ,  C07D487/04 ,  A61N5/10 ,  C07C2601/16

CPC分类号： A61K31/495 ,  A61K9/0043 ,  A61K31/045 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61N5/10 ,  C07B59/00 ,  C07B2200/05 ,  C07C33/14 ,  C07C2601/16 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04

摘要： The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

公开(公告)号：US20170360037A1

公开(公告)日：2017-12-21

申请号：US15695296

申请日：2017-09-05

申请人： Valent BioSciences LLC

发明人： Gary T. Wang ,  Daniel F. Heiman ,  Gregory D. Venburg ,  Eiki Nagano ,  Marci Surpin ,  Joseph H. Lustig

IPC分类号： A01N37/42 ,  C07C255/31 ,  C07C253/30 ,  C07C235/78 ,  C07C69/738 ,  C07C51/16 ,  C07C59/90 ,  C07D277/64 ,  C07C231/12 ,  C07C2601/02 ,  C07C2601/16 ,  C07C2601/04

CPC分类号： A01N37/42 ,  A01N43/78 ,  A01N53/00 ,  C07B2200/07 ,  C07C51/16 ,  C07C59/90 ,  C07C67/44 ,  C07C69/738 ,  C07C231/12 ,  C07C235/78 ,  C07C253/30 ,  C07C255/31 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/16 ,  C07D277/64

摘要： The invention relates to a novel class of (S)-3′-substituted-abscisic acid derivatives and (±)-3′-substituted-abscisic acid derivatives, and methods of synthesizing the derivatives.

公开(公告)号：US20170297991A1

公开(公告)日：2017-10-19

申请号：US15411861

申请日：2017-01-20

申请人： BioElectron Technology Corporation

发明人： Paul Mollard

IPC分类号： C07C46/06 ,  C07C2601/16

CPC分类号： C07C46/06 ,  C07C403/08 ,  C07C2601/16 ,  C07D311/72 ,  C07C50/28

摘要： A method of producing alpha-tocotrienol quinone or a stereoisomer thereof, the method comprising selective opening of alpha-tocotrienol chroman to alpha-tocotrienol quinone in the presence of non-alpha tocotrienol chromans by oxidizing alpha-tocotrienol with a metal salt oxidizing agent, wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least 4:1 and wherein said metal oxidizing agent is added in sequential additions, in order to reduce oxidation of any amounts of non-alpha tocotrienol chromans that might have been present in the starting alpha-tocotrienol chroman material. This process uses conditions favoring oxidation rates of the alpha tocotrienol chroman vs. the non-alpha tocotrienol chromans.

公开(公告)号：US20170373251A1

公开(公告)日：2017-12-28

申请号：US15536778

申请日：2015-12-16

申请人： Novaled GmbH

发明人： Markus Hummert ,  Achim Bruch ,  Christiane Köhn ,  Max P. Nüllen ,  Ulrich Heggemann

IPC分类号： H01L51/00 ,  C07D213/84 ,  C09K11/06 ,  C07C255/51 ,  C07D239/30 ,  H01L51/50 ,  C07C2601/16 ,  C07C2601/02

CPC分类号： H01L51/005 ,  C07C255/35 ,  C07C255/51 ,  C07C2601/02 ,  C07C2601/16 ,  C07D213/84 ,  C07D239/30 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1018 ,  H01L51/001 ,  H01L51/0067 ,  H01L51/506 ,  H01L51/5088 ,  H01L2251/554

摘要： The present invention relates to a process for preparation of an electrically doped semiconducting material comprising a [3]-radialene p-dopant or for preparation of an electronic device containing a layer comprising a [3]-radialene p-dopant, the process comprising the steps: (i) loading an evaporation source with the [3]-radialene p-dopant; and (ii) evaporating the [3]-radialene p-dopant at an elevated temperature and at a reduced pressure, wherein the [3]-radialene p-dopant is selected from compounds having a structure according to formula (I) wherein A1 and A2 are independently aryl- or heteroaryl-substituted cyanomethylidene groups, the aryl and/or heteroaryl is selected independently in A1 and A2 from 4-cyano-2,3,5,6-tetrafluorphenyl,2,3,5,6-tetrafluorpyridine-4-yl, 4-trifluormethyl-2,3,5,6-tetrafluorphenyl, 2,4-bis(trifluormethyl)-3,5,6-trifluorphenyl, 2,5-bis(trifluormethyl)-3,4,6-trifluorphenyl, 2,4,6-tris(trifluormethyl)-1,3-diazine-5-yl, 3,4-dicyano-2,5,6-trifluorphenyl, 2-cyano-3,5,6-trifluorpyridine-4-yl, 2-trifluormethyl-3,5,6-trifluorpyridine-4-yl, 2,5,6-trifluor-1,3-diazine-4-yl and 3-trifluormethyl-4-cyano-2,5,6-trifluophenyl), and at least one aryl or heteroaryl is 2,3,5,6-tetrafluorpirydine-4-yl, 2,4-bis(trifluormethyl)-3,5,6-trifluorphenyl, 2,5-bis(trifluormethyl)-3,4,6-trifluorphenyl, 2,4,6-tris(trifluormethyl)-1,3-diazine-5-yl, 3,4-dicyano-2,5,6-trifluorphenyl, 2-cyano-3,5,6-trifluorpyridine-4-yl, 2-trifluormethyl-3,5,6-trifluorphenyl, provided that the heteroaryl in both A1 and A2 cannot be 2,3,5,6-tetrafluorpyridine-4-yl at the same time, respective [3]-radialene compounds, and semiconducting materials and layer, and electronic devices comprising said compounds.

公开(公告)号：US20170369447A1

公开(公告)日：2017-12-28

申请号：US15697301

申请日：2017-09-06

申请人： Senomyx, Inc.

发明人： Lyudmyla Chumakova ,  Andrew Patron ,  Chad Priest ,  Donald Karanewsky ,  Rachel Kimmich ,  Brant Clayton Boren ,  Jeffrey Robert Hammaker ,  Volodymyr Chumakov ,  Wen Zhao ,  Alain Noncovich ,  Jane Ung

IPC分类号： C07D231/20 ,  A23L33/10 ,  C07D403/06 ,  C07D401/06 ,  C07D333/22 ,  C07D239/62 ,  C07D239/22 ,  C07D235/02 ,  C07D233/78 ,  C07D213/50 ,  C07D207/333 ,  C07D207/32 ,  C07D207/26 ,  C07C233/31 ,  C07D405/06 ,  A23L2/52 ,  C07D409/06 ,  C07C2601/04 ,  C07C2601/16

摘要： The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

公开(公告)号：US20170313662A1

公开(公告)日：2017-11-02

申请号：US15516206

申请日：2015-10-01

申请人： Laurus Labs Private Limited

发明人： Kameswar Rao Chivukula ,  Veera Karuturi ,  Rao Venkateswara ,  Srinivas Benda ,  Ramachandra Anke ,  Dharmapuri Gajula ,  Venkata Rama Krishna Murt Moturu ,  Venkata Sunil Kumar Indukuri ,  Seeta Rama Anjaneyulu Gorantla ,  Satyanarayana Chava

IPC分类号： C07D233/86 ,  C07C25/13 ,  C07C22/08 ,  C07C331/28 ,  C07C255/49 ,  C07C2601/16

CPC分类号： C07D233/86 ,  C07C22/08 ,  C07C25/13 ,  C07C255/49 ,  C07C331/28 ,  C07C333/08 ,  C07C335/22 ,  C07C335/26 ,  C07C2601/16

摘要： The present invention relates to an improved process for the preparation of enzalutamide by conventional synthesis, which avoids utilization of microwave irradiation and noxious reagents. The present invention also relates to an improved process for preparation of 4-isothiocyanato-2-(trifluoromethyl) benzonitrile, which is an intermediate in the synthesis of Enzalutamide.

公开(公告)号：US20170305849A1

公开(公告)日：2017-10-26

申请号：US15509905

申请日：2015-08-11

申请人： BASF SE

发明人： Bernd SCHÄFER ,  Stefan BENSON ,  Wolfgang SIEGEL

IPC分类号： C07C403/24 ,  C07C2601/16

CPC分类号： C07C403/24 ,  C07C2601/16

摘要： The invention describes an environmentally friendly, sustainable and cost-effective method for preparing astaxanthin diesters of the formula 1, in which astaxanthin of the formula 2 is doubly esterified with fatty acid chlorides of the general formula 3. For this purpose, compound 2 and 3 are reacted in an organic solvent in the presence of a nitrogen-containing base of the general formula 4. The invention further relates to the non-therapeutic use of the diester 1, in which R is a residue selected from the group consisting of C13-C19-alkyl, C13-C19-alkenyl, C13-C19-alkdienyl and C13-C19-alktrienyl, in human or animal nutrition and also the therapeutic use of the diester 1 prepared according to the method as a medicament and also as an ingredient in a medicinal preparation.

公开(公告)号：US20180000749A1

公开(公告)日：2018-01-04

申请号：US15536603

申请日：2015-12-16

申请人： Bioelectron Technology Corporation

发明人： Paul MOLLARD ,  Christopher R. CORNELL ,  Kieron E. WESSON ,  Peter GIANNOUSIS ,  Shazad SUCHIT ,  Mahmoud MIRMEHRABI

IPC分类号： A61K31/122 ,  C07C215/08 ,  A61K31/164 ,  C07C231/12 ,  C07C215/28 ,  C07C2601/16

CPC分类号： A61K31/122 ,  A61K31/164 ,  C07B57/00 ,  C07B2200/13 ,  C07C215/08 ,  C07C215/28 ,  C07C215/30 ,  C07C231/12 ,  C07C235/78 ,  C07C2601/16

摘要： Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.

公开(公告)号：US20170355670A1

公开(公告)日：2017-12-14

申请号：US15526962

申请日：2015-11-17

申请人： BASF SE

发明人： Stefan RÜDENAUER ,  Ralf PELZER ,  Miriam BRU ROIG ,  Vijay Narayanan SWAMINATHAN ,  Shrirang HINDALEKAR ,  Nitin GUPTE ,  Prachin KOLAMBKAR

IPC分类号： C07C403/16 ,  C11B9/00 ,  C07C29/17 ,  A23L27/20 ,  C07C2601/16 ,  C07C2601/14

CPC分类号： C07C403/16 ,  A23L27/203 ,  C07C29/175 ,  C07C2601/14 ,  C07C2601/16 ,  C11B9/0034 ,  C07C31/1355

摘要： The present invention relates to a process for the preparation of 1-(2,6,6-trimethylcyclohexylyalkan-3-ols, in particular 1-(2,6,6-trimethylcyclohexyl)-hexan-3-ol. The invention further relates to 5-alkoxy-1-(2,6,6-trimethylcyclohexenyl)-1-alken-3-ones and the use of these as a fragrance or as flavor, to a fragrance containing composition and/or a fragranced product containing 5-alkoxy-1-(2,6,6-trimethylcyclohexenyl)-1-alken-3-ones and to a method for imparting or modifying a scent or a flavor to a composition by including said alkoxyalkenones into such composition.

公开(公告)号：US20170349517A1

公开(公告)日：2017-12-07

申请号：US15609159

申请日：2017-05-31

申请人： Daniel Dickman ,  Emerich Eisenreich ,  Daniel Levin ,  Mackenzie Marrs

发明人： Daniel Dickman ,  Emerich Eisenreich ,  Daniel Levin ,  Mackenzie Marrs

IPC分类号： C07C39/23 ,  C07C37/68 ,  C07C2601/16

CPC分类号： C07C39/23 ,  C07B2200/13 ,  C07C37/68 ,  C07C2601/16

摘要： Solid cannabidivarin, crystalline cannabidivarin, (R,R)-(−)-crystalline cannabidivarin, (S,S)-(+)-crystalline cannabidivarin and substantially pure forms thereof are disclosed herein. Further disclosed are methods of making such cannabidivarin, compositions and formulations comprising such cannabidivarin, and methods of treating disease with such cannabidivarin.