- 专利标题： Predicting Genetically Stable Recombinant Protein Production In Early Cell Line Development
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申请号： US15525315申请日： 2015-11-12
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公开(公告)号： US20170314082A1公开(公告)日： 2017-11-02
- 发明人: Uros Jamnikar , Kristina Gruden
- 申请人： Lek Pharmaceuticals d.d.
- 申请人地址： SI Ljubljana
- 专利权人： Lek Pharmaceuticals d.d.
- 当前专利权人： Lek Pharmaceuticals d.d.
- 当前专利权人地址： SI Ljubljana
- 优先权： EP14192809.3 20141112
- 国际申请： PCT/EP2015/076390 WO 20151112
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N5/073
摘要：
The present invention relates in general to the field of recombinant protein expression. In particular, the present invention relates to a method for selecting a suitable candidate cell clone for recombinant protein expression and to a host cell for recombinant protein expression, the host cell exhibiting artificially modified gene expression of at least one gene selected from the group consisting of: Hist1h2bc, Egrl, BX842664.2/Hist 1h3c, Dhfr, Fgfr2, AC115880.11, Mmp10, Vsnll (optional), CU459186.17, El 30203 B14Rik, Cspg4, C1qtnf1, Foxp2, and Ptpre.
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