- 专利标题： Spirocyclic Heterocyclic Compounds Useful As HIV Integrase Inhibitors
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申请号： US15533169申请日： 2015-12-04
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公开(公告)号： US20170334924A1公开(公告)日： 2017-11-23
- 发明人: Mark W. Embrey , Thomas H. Graham , Izzat T. Raheem , John D. Schreier , Sherman T. Waddell , John S. Wai , Lihong Hu , Xuanjia Peng
- 申请人： Mark W. Embrey , Thomas H. Graham , Izzat T. Raheem , John D. Schreier , Sherman T. Waddell , John S. Wai , Lihong Hu , Xuanjia Peng
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 优先权： CNPCT/CN2014/093335 20141209
- 国际申请： PCT/US15/63850 WO 20151204
- 主分类号： C07D491/20
- IPC分类号： C07D491/20 ; C07D487/20 ; A61K45/06 ; A61K31/683 ; A61K31/675 ; C07F9/6561 ; A61K31/499
摘要：
The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R4 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
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