- 专利标题： BISPECIFIC OR-GATE CHIMERIC ANTIGEN RECEPTOR RESPONSIVE TO CD19 and CD20
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申请号： US15535972申请日： 2015-12-14
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公开(公告)号： US20170368098A1公开(公告)日： 2017-12-28
- 发明人: Yvonne Y. CHEN , Eugenia ZAH , Michael C. JENSEN
- 申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SEATTLE CHILDREN'S HOSPITAL DBA SEATTLE CHILDREN'S RESEARCH INSTITUTE
- 国际申请： PCT/US2015/065620 WO 20151214
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; C07K14/725 ; C07K16/28 ; C12N5/0783 ; C07K16/46 ; C07K14/705 ; A61K39/00 ; A61K38/00
摘要：
A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.
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