Invention Application
- Patent Title: 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
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Application No.: US15499824Application Date: 2017-04-27
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Publication No.: US20180051015A1Publication Date: 2018-02-22
- Inventor: Thomas Raymond CAFERRO , Zhuoliang CHEN , Young Shin CHO , Abran Q. COSTALES , Julian Roy LEVELL , Gang LIU , James R. MANNING , Martin SENDZIK , Cynthia SHAFER , Michael David SHULTZ , James Clifford SUTTON , Yaping WANG , Qian ZHAO
- Applicant: NOVARTIS AG
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D417/14 ; C07D413/04 ; A61K31/506 ; A61K31/5377

Abstract:
The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
Public/Granted literature
- US10112931B2 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH Public/Granted day:2018-10-30
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