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公开(公告)号:US20240360082A1
公开(公告)日:2024-10-31
申请号:US18291083
申请日:2022-07-22
Applicant: NOVARTIS AG
Inventor: Graham Charles BLOOMFIELD , Matthew James HESSE , Richard Yichong HUANG , Michael Robert MASER , James Clifford SUTTON , Benjamin Robert TAFT , David Charles TULLY
IPC: C07D213/82 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K31/553 , C07D401/10 , C07D401/12 , C07D405/10 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/052 , C07D493/08 , C07D493/10 , C07D498/04 , C07D498/08 , C07D498/10
CPC classification number: C07D213/82 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K31/553 , C07D401/10 , C07D401/12 , C07D405/10 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/052 , C07D493/08 , C07D493/10 , C07D498/04 , C07D498/08 , C07D498/10
Abstract: The disclosure provides compounds of Formula (I): (I) as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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公开(公告)号:US20180057501A1
公开(公告)日:2018-03-01
申请号:US15686652
申请日:2017-08-25
Applicant: Novartis AG
Inventor: Rama JAIN , Dennis Christofer KOESTER , James R. MANNING , Vanessa MARX , Daniel POON , James Clifford SUTTON , Benjamin R. TAFT , Lifeng WAN , Aregahegn YIFRU , Qian ZHAO
IPC: C07D487/14 , C07D498/14 , C07D471/14
CPC classification number: C07D487/14 , C07D471/14 , C07D498/14
Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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公开(公告)号:US20180051015A1
公开(公告)日:2018-02-22
申请号:US15499824
申请日:2017-04-27
Applicant: NOVARTIS AG
Inventor: Thomas Raymond CAFERRO , Zhuoliang CHEN , Young Shin CHO , Abran Q. COSTALES , Julian Roy LEVELL , Gang LIU , James R. MANNING , Martin SENDZIK , Cynthia SHAFER , Michael David SHULTZ , James Clifford SUTTON , Yaping WANG , Qian ZHAO
IPC: C07D413/14 , C07D417/14 , C07D413/04 , A61K31/506 , A61K31/5377
CPC classification number: C07D413/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/04 , C07D417/14
Abstract: The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
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公开(公告)号:US20250011334A1
公开(公告)日:2025-01-09
申请号:US18743020
申请日:2024-06-13
Applicant: Novartis AG
Inventor: Rama JAIN , Dennis Christofer KOESTER , James R. MANNING , Vanessa MARX , Daniel POON , James Clifford SUTTON , Benjamin R. TAFT , Lifeng WAN , Aregahegn YIFRU , Qian ZHAO
IPC: C07D487/14 , A61K31/5025 , A61K31/53 , A61K31/5365 , A61K31/5383 , A61K31/551 , A61P31/16 , C07D471/14 , C07D498/14
Abstract: The invention provides compounds of Formula (1): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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公开(公告)号:US20200347072A1
公开(公告)日:2020-11-05
申请号:US16933000
申请日:2020-07-20
Applicant: Novartis AG
Inventor: Rama JAIN , Dennis Christofer KOESTER , James R. MANNING , James Clifford SUTTON , Benjamin Robert TAFT , Lifeng WAN , Qian ZHAO
IPC: C07D487/14 , C07D471/14 , C07D491/22 , C07D498/14 , A61P31/16 , C07D513/14
Abstract: The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: (I) and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.
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公开(公告)号:US20190092780A1
公开(公告)日:2019-03-28
申请号:US16083089
申请日:2017-03-07
Applicant: Novartis AG
Inventor: Rama JAIN , Dennis Christofer KOESTER , James R. MANNING , James Clifford SUTTON , Benjamin Robert TAFT , Lifeng WAN , Qian ZHAO
IPC: C07D487/14 , C07D471/14 , C07D491/22 , C07D513/14 , C07D498/14 , A61P31/16
Abstract: The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.
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