Invention Application
- Patent Title: SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS
-
Application No.: US15809437Application Date: 2017-11-10
-
Publication No.: US20180079758A1Publication Date: 2018-03-22
- Inventor: Douglas G. Batt , Myra Beaudoin Bertrand , George V. Delucca , Michael A. Galella , Soo Sung Ko , Charles M. Langevine , Qingjie Liu , Qing Shi , Anurag S. Srivastava , Joseph A. Tino , Scott Hunter Watterson
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Main IPC: C07D513/04
- IPC: C07D513/04 ; C07D471/04 ; C07D403/10 ; C07D209/88 ; C07D239/70

Abstract:
Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R1 is F, Cl, —CN, or —CH3; R2 is Cl or —CH3; R3 is —C(CH3)2OH or —CH2CH2OH; Ra is H or —CH3; each Rb is independently F, Cl, —CH3, and/or —OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
Public/Granted literature
- US10106559B2 Substituted tetrahydrocarbazole and carbazole carboxamide compounds Public/Granted day:2018-10-23
Information query